Association of glutathione s-transferase pi (GSTP1) gene polymorphism in unexplained infertile women

15–20 million people in India are affected by infertility.Among them, 34% of the couples shown to have unexplained infertility (UEI). Both genetic and environmental factors influence UEI. Data from various studies show that oxidative stress plays an important role infertility. The genes phase II detoxification enzyme, Glutathione s-transferase family upregulated humans as a defense mechanism opposing adverse effects play during pregnancy. Since all investigations for work-up normal evaluating causes UEI will impact on treatment protocol. In this study association between GSTP1 variations discussed. To compare polymorphism women with control group. : This is case 70 ovulatory who conceived within 12 months contraceptive free intercourse, no history miscarriage were recruited group All participants included 28 38 years age. studied using real-time PCR Light Cycler instrument (Roche Applied Science). variant allele frequencies 0.39 0.41for cases respectively. results indicate polymorphisms did not significant infertile